Podcasts on Longevity Science and Economics

As I noted a little while ago, the SAGE Crossroads website rose from the dead this year to restart its series of podcasts on aging research and longevity science, with a focus on policy matters and publicly funded research. That slant isn't quite my cup of tea, but each to their own. The most recent four podcasts are themed on economics:

What do the current economic models say about longevity?

KYLE JENSEN: The audience of the SAGE Crossroads website is made up of scientists, policy makers, and curious consumers. If there is one last statement you would like to make to them regarding the economics and longevity science in the future, what would it be?

ROBERT FOGEL: Don’t be afraid of it; it’s actually the leading industry. The demands of healthcare are going to pull all other industries forward. Of course they require new technologies in steel and heavy industry and as well as delivery systems. I think they should be looked at positively. Again I say if this were a privatized system, we would all say “gee it’s wonderful. All these people want more health care, this industry is thriving”. Let me put one other analogy. Suppose we made cars a government entitlement. Instead of cheering when auto production went up, we’d say, “Oh my God, we can’t afford this!”. How you finance it may greatly affect the psychology and actually the freedom of the economy to take advantage of these new opportunities.

Which is interesting, as this fellow spends the rest of his talk telling us that government entitlements are great and can always be fixed if they're not. "Fixed" is a word that springs to mind, yes, but not in the sense of "repaired."

How does longevity science contribute to the economy?

KYLE JENSEN: Mr. Perry, how have developments in aging research, longevity science, and public health affected the ways that Americans live the 65 plus years of their life?

DANIEL PERRY: Well, we are probably too close to the changes to appreciate them and to understand them, but we’ve really succeeded in scrambling the images of life’s mileposts of aging. We’ve added 50% to average life expectancy in the last 100 years, and all of the studies suggest that people are not only living longer, but they are living with less disability and they are healthier than any other time we have known in the past. The short hand for this is to say that 50 is the new 30 or that 65 and 70 are still the prime years of life, and I wouldn’t be a bit surprised if we were going to be saying that 85 is the new 60 before very long. In fact, at age 65, which at one point most Americans considered the beginning of the end if you will, most Americans can count on living another 18 years of life, and half of them will live past 90. All of this has had huge positive economic impact. The vast majority of people at middle age are now saying in surveys that they expect to work well past retirement age, traditional retirement age, half expect to work into their 70s, either because they need to or because they want to stay working and engaged.

Measuring the economic benefits of medical research and longevity science

KYLE JENSEN: Your work also seems to argue that longer, healthier life is very valuable yet historically undervalued and conservative. Why do you believe this is true?

DAVID MELTZER: Well, so the way I like to think of it is in terms of length of life and quality of life. So a lot of work in medical cost effective analysis and in other areas have tried to determine the gains to health in terms of both length of life and quality of life. You then weigh those gains versus the costs of the interventions that produce them. What my work is focused on, or at least an aspect of my work, is understanding how extensions of life create costs in ways that may not be obvious. So, for example, when you live longer, you have more years in which you have to support the cost of being alive, medical expenditures. Conversely, if you're living longer and working, you take earnings away from that. It's traditionally been the case that fields of medical cost effective analysis haven't included costs of living longer. As a result, cost effectiveness has also systematically underestimated the costs of life extending interventions. In contrasts, interventions that improve the quality of life don't have these costs due to length of life. As a result, there has tended to be a bias in traditional methods of cost effective analyses. You spend too much money on things that make you live longer relative to things that improve the quality of life. And that's been one of the major focuses in the work that I've done on cost effectiveness.

This way of looking at things is very much a function of the limited medical technology of today. When you can ensure increased longevity with accompanying extension of health - which is very much not the focus of mainstream aging and late-life disease research today - economic problems go away. Daniel Perry has it right: a healthy, working person at any age is a net producer of wealth. The more healthy people that exist, and the longer they live, the more wealth is produced.

Trying to find any economic benefit or trade-off in loss of function and aging to death is a form of the broken window fallacy. Destruction is always, exactly, and only destruction - there is no gain that comes from it.

Why living longer can only be beneficial to society

KYLE JENSEN: Do you feel that Americans that are living longer would impact social security, Medicare, and various other entitlement fields negatively?

GREGORY STOCK: Well, they certainly should impact those programs. The question is that these kinds of programs which always come up in these kinds of discussions are set up so that people when they are no longer functional and vital are able to be supported in some way by society, so if you have much, much older people chronologically that can be fully active and participate in society, then they should have to do that or should have to provide for themselves. And, you know, the other point of it is that something like social security is already going to be bankrupt, so of course if you have people living longer and you don’t make any adjustments and you try to support a large segment of the population that isn’t going to be a good solution.

KYLE JENSEN: Do you think we are on the right track to revamp those programs?

GREGORY STOCK: I don’t think we’re doing much at all, but those things will clearly occur and the political process will allow them to occur and will force them to occur when there is a real problem that is proximate rather than some real distant thing that can be passed off or left to the next generation or to later politicians.

Radical change is certainly ahead, as the present culture of entitlements and forced wealth transfer is barely sustainable even without the near future technologies of healthy life extension. Something has to give, and the longer the present political system lasts, the worse off we'll all be.

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Should the Link of the Day Stay?

graphic_link_150 I have a question, guys and gals. Every day for the past month, I have pointed out a Link of the Day. I did this because I run across so many great sites everyday in my regular web browsing, and I felt that these needed to be shared with you.

I honestly can not tell how many of you are liking or disliking this post everyday. Does it get in the way of regular content or do you find the links useful?

Please take a little poll for me. Should the Link of the Day Stay? I will keep the poll open for just a few days, so please select yes or no now.

Thanks!

image (c) Teri Cosenzi

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Surround Yourself in a Tropical Paradise with LAVANILA’s Vanilla Coconut.

Those of you who read Beautiful Makeup Search or The Fragrance Fanatic are probably sick of hearing this already, but I have a new scent for Summer. And it is dreamy and tropical and - ooooh so perfect for the season.

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LAVANILA Vanilla Coconut is the most perfect blend of coconut and vanilla - well, with a few other notes mixed in - that leaves me feeling and smelling like I am in a tropical paradise. I kid you not.

Notes:
Coconut, Tiare Flower, Heliotrope, Sandalwood, Madagascar Vanilla.

I am so overly sensitive to fragrance and I rarely find one that I like, let alone love. And pleasing the husband with a fragrance can be even more difficult. This one, surprisingly, has pleased us both - and I cannot get enough of it. So much so that I will be adding the rest of the collection to my beauty stash. There is a Vanilla Coconut Body Butter ($25), and a Vanilla Coconut Healthy Lip Shine ($14).  The 1.7 oz. Eau de Parfum Spray that I am using sells for $56.

LAVANILA is available at Sephora and Sephora.com. I dare you not to love this!

Be sure to check out next month’s blog of the month, The Scented Life, for more wonderful fragrance ramblings including some more scents of Summer.

image credit: Sephora

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Link of the Day - June 29, 2008.

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If you are ever sitting at your desk and need a quick beauty fix, look no further than you very own standard office supplies. Here is an article with the tricks needed and what to use to help in your quandary. Check it out!

image (c) Teri Cosenzi

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Link of the Day - June 28, 2008.

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Need to slough off some of that dry Summer skin. If you don’t have an exfoliant product by the ready, you can make your own with baking soda. Simple? Yes - check out this article for how to do this.

image (c) Teri Cosenzi

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Simply the Splendid Best of the Week!

From the Splendicity community, comes this week’s best in Beauty, Fashion and Shopping.

BEAUTY
The Fragrance Fanatic tells you some great ways to Wear Your Fragrance.

Aging Fabulous introduces us to Boots No7 Protect & Perfect Body Serum.

Beauty Banter asks celebrity makeup artists how to do a white eyelid right… must-have application tips and products for a fierce, summer white eye!

A Touch of Blusher looks at Dior’s fall 2008 makeup collection.

The Scented Life is excited to hear that Justin Timberlake will be the face of Givenchy’s new cologne, Play.

15 Minute Beauty Fanatic finally finds a great concealer that will cover up her undereye area all day! It’s Tarte’s The Eraser!

Beautiful Makeup Search picks out some products from the Shu Uemura 25th Boutique Birthday collection.

Steeping Beauty Gets Smart with Peter Thomas Roth’s Un-Wrinkle Pressed Powder!

FASHION
Wardrobe Oxygen offers some suggestions to give a modern and youthful look to your makeup routine.

The Well-Heeled Society shows you a worthwhile shoe investment, available in a spectrum of colors from Ralph Lauren.

She Knows Best is glad to report that David Arquette has redeemed himself.

Style Tots is giving away a Tutu from Prissy Poofs.

Snarkstress marvels that the potentially future First Lady, Michelle Obama, is an off-the-rack shopper - and is creating quite a frenzy in the process.

The Fashionable Kiffen asks “Denim or Not?”

SHOPPING
Style It Less offers up an Under $100 Look with a belted tunic, jeans and a Christian Louboutin Pumps replica.

Teen Style Lounge invites you to get your cute on with this summery (and cheap!) sundress and accessories outfit from Forever 21.

Have a splendid weekend!

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Friday Science: Aging, Stem Cells and Stem Cell Niches

I notice that two good review papers on the topic of stem cells, stem cell niches and aging are presently freely available in the latest Aging Cell. Journal publishers tend to put out these free full text promotions for a limited time, so take a look while the looking is there.

Stem Cell Review Series: Aging of the skeletal muscle stem cell niche

Declining stem cell function during aging contributes to impaired tissue function. Muscle-specific stem cells ('satellite cells') are responsible for generating new muscle in response to injury in the adult. However, aged muscle displays a significant reduction in regenerative abilities and an increased susceptibility to age-related pathologies. This review describes components of the satellite cell niche and addresses how age-related changes in these components impinge on satellite cell function.

You can find more about satellite cells and the aging stem cell niche back in the Fight Aging! archives as well. Just follow those links.

Stem Cell Review Series: Regulating highly potent stem cells in aging: environmental influences on plasticity

Significant advances in the past decade have revealed that a large number of highly plastic stem cells are maintained in humans through adulthood and are present even in older adults. These findings are notable in light of the reduced capacity for repair and regeneration in older tissues. The apparent dichotomy can be reconciled through an appreciation of the age-associated changes in the microenvironmental pathways that govern adult stem cell plasticity and differentiation patterns.

As this second paper illustrates, the weight of evidence is shifting to the view that we are packed full of functional stem cells even as we age. These stem cell populations are shut down by changes in biochemical signals and systems, possibly due to accumulated damage that causes aging and malfunction, possibly as an evolved defense against the increasing likelihood of cancer in old tissue. As cancer medicine becomes increasingly sophisticated, safe and effective, learning the signals to set our stem cells back to work begins to look like a plausible near term strategy for enhancing longevity.

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L’Oreal Skin Genesis.

The product development team over at L’Oreal has stepped it up a notch. Their new-ish line of Skin Genesis products are amazing. When I saw that their main ingredient mix of Pro-Xylane + Hyaluronic work together to help the skin to strengthen as well brighten and tighten, I knew I needed them.

I have been using the L’Oreal Skin Genesis Multi-Layer Cell Strengthening Daily Treatment together with the Multi-Layer Cell Strengthening Daily Moisturizer for a few weeks now. My initial reaction - I am impressed.

My main concern I have with my face, well amongst the fine lines, is brightening. I strive for an overall even skin tone, which I have never had. And by using skin brightening products, I sometimes see results. I can say that I have not seen such as quick of an improvement, than I have with these two products. I think the results are so great as these products work layer upon layer, building deep into the skin - not just on the surface.

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Here is more about this multi-layer cell strengthening system and ingredients:

L’Oreal Research has developed patented Pro - Xylane™, a superior naturally - derived molecule so small it can penetrate skin’s surface layers.  Combined with Hyaluronic Spheres, this complex boosts cell activity layer by layer to strengthen skin.

Pro - Xylane™: A Unique Ingredient

  • 100% naturally - derived from an environmentally friendly process called “Green Chemistry”
  • Bio - assimilable, bio - degradable
  • Delivered in an airless pump to protect its purity.

Skin Strengthening Benefits

  • Builds strength deep within skin’s surface.  Reinforces skin’s matrix to add fullness, improve elasticity and renew skin’s evenness from within.
  • Strengthens between skin’s layers.  Helps promote healthy collagen production to fortify skin’s structure and support*.
  • Smoothes the surface layer.  Boosts cellular renewal to help erase fine lines, and instantly hydrates for more even, light - reflective skin.

Both of the serum and moisturizer have a light weight feel to them, and spread easily onto skin. They are both lightly fragranced and come in fantastic airless pumps. I use only one pump of the serum for my face and neck, but two or sometimes three pumps of the moisturizer, depending on how fry I feel. The moisturizer even seems to have a bit of iridescence to it - to instantly brighten while it works deep.

I will continue to use these products for sure. And the price and availability of L’Oreal products are a great plus as well. The Daily Treatment Serum and Daily Moisturizer both sell for $19.99 and sell nationwide at major drugstores. Actually, next time Ii am in CVS, I plan to pick up the Eye Serum as I have heard raves about that one before.

To read about how other users feel about the Skin Genesis products from L’Oreal, head on over on Total Beauty.

image’s credit: L’Oreal

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Link of the Day - June 27, 2008.

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Today’s link is to one of our very own in the Beauty & Style Channel. As Indie Style File is still our Blog of the Month, I figured that I would link back to this wonderful blog one more time before the month was over.

image (c) Teri Cosenzi

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Legitimacy and Funding for the Fight to End Aging

A timely piece in Wired today:

Gandhi once said, describing his critics, "First they ignore you, then they laugh at you, then they fight you, then you win."

After declaring, essentially out of nowhere, that he had a program to end the disease of aging, renegade biogerontologist Aubrey de Grey knows how the first three steps of Gandhi's progression feel. Now he's focused on the fourth.

"I've been at Gandhi stage three for maybe a couple of years," de Grey said. "If you're trying to make waves, certainly in science, there's a lot of people who are going to have insufficient vision to bother to understand what you're trying to say."

This weekend, his organization, The Methuselah Foundation, is sponsoring its first U.S. conference on the emerging interdisciplinary field that de Grey has helped kick start. (Its first day, Friday, will be free and open to the public.) The conference, Aging: The Disease - The Cure - The Implications, held at UCLA, is an indication of how far de Grey has come in mainstreaming his ideas.

The Methuselah Foundation's research is beginning to produce results:

In research that will first be presented on Friday at the conference, Methuselah-funded scientists will demonstrate a proof-of-concept experiment for using bacterial enzymes to fight atherosclerosis, or the hardening of the arteries. That's an idea that de Grey has been pushing for years.

The signs continue to be promising for the Methuselah Foundation to be the boulder that leads the avalanche, gathering legitimacy and researchers to the task of repairing aging at an accelerating rate. Those folk who helped to get this initiative off the ground back in 2004 should be feeling pretty pleased right about now.

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